Nitric oxide has important functions in cardiovascular, neurological, immunological and many biological systems). Noni (Morinda citrifolia) has been found to have antitumor, antiproliferative, proapoptotic, anti-angiogenesis, anti-migratory, anti-inflammatory and immunomodulatory activities. The aim of this study is to determine some antioxidant activities in food supplement mixture fruit containing Noni (Morinda citrifolia), Vitamin B3, Zinc, Vitamin B1, CoenzymeQ10 and Chromium. In this study, antioxidant activities were determined by spectrophotometric method. While the MDA level was found to be 0.0012 (mmol/L); the SOD activity was 1377.483 (U/L); reduced glutathione (GSH) level 725.251(mg/dl); catalase (CAT) activity 1275.035 (U/L); glutathione reductase  activity (GR) 1439.041 (U/L), and glutathione peroxidase (GPx) activity were found to be 1215.055 (U/L). Some antioxidant activities such as SOD, GR, GST, GPx, GSH and CAT were found to be high in the noni fruit. Malondialdehyde (MDA) level was found to be low. Antioxidant activities were found to be very high in the noni extract. Noni fruit or its extract can be consumed against oxidative stress. We think that this study will contribute to the literature.