Brucellosis is a zoonotic disease that can lead to a variety of clinical manifestations. This disease, which is endemic in Mediterranean countries including Turkey, is of interest to many specialties due to its multisystem involvement.  In this article, we aimed to investigate the lesser-known aspects of brucellosis by examining the psychiatric symptoms associated with this old and persistent disease, to review the published literature on a global level, and to reveal the contribution from our country. Beyond the physical burden of brucellosis, it is crucial to recognize and address the psychiatric effects that this disease can have on individuals.  By raising awareness about the psychiatric aspects of brucellosis, healthcare providers can implement comprehensive care strategies that encompass both physical and mental health support. Integrating psychiatric assessment, counseling and appropriate pharmacological interventions is essential to reduce the negative psychiatric impact of brucellosis and promote holistic recovery. Once understood primarily as a physical disorder, the potential impact of brucellosis on mental health is now recognized. The psychiatric effects of brucellosis can range from mood disorders and cognitive impairment to psychotic symptoms and sleep disturbances. Understanding the mechanisms and risk factors underlying these psychiatric symptoms is vital for developing effective interventions and providing holistic care. By shedding light on this often-overlooked aspect of brucellosis, medical professionals can improve patient outcomes and enhance the quality of life of those affected by this infectious disease.