Over the past few decades, there has been significant progress in understanding MSC therapy and its antimicrobial effects, leading to a substantial body of literature in this field. MSC-based therapy has emerged as a charming option for treatment modalities, serving as a cellular rehabilitative therapy for various diseases, particularly inflammatory conditions. Despite several clinical trials examining MSC-based therapies to struggle bacterial infections, there are currently insufficient studies specifically focused on vaginal candidiasis. The feasibility of autologous MSC and their targeted delivery to specific cells has resulted in their extensive utilization across various treatment fields. Although there are existing limitations, the transplantation of MSCs represents a remarkable and inspiring approach in the scope of medical science, necessitating further data collection to explore their potential in addressing vaginal candidiasis. Further efforts are warranted to improve efficient therapy using MSCs in therapeutic approaches. Depending upon the findings in pre-clinical experiments, it is crucial to further investigate the antifungal activities of MSCs and conduct translational studies to appreciate their clinical applications. This concise chapter aims to promote such endeavours in the remedial approaches of MSC for the treatment of vaginal candidiasis.