With the Digital Transformation, the preferences of both individuals change and the way of doing business and management of organizations are completely restructured. For Turkey, the sector most affected by Digital Transformation is the Banking Sector. The Banking Sector is very important both in terms of demand and increasing production capacities and development. From the perspective of our country, the sector has advanced technology and qualified employees. During the global pandemic, The Banking Sector had to fit the investments in a span of as short as two years which should have been made in ten years. As a result of this rapid change, many factors such as being overloaded, being constantly online, changing the way of doing business, complexity, work-life balance uncertainties have caused work stress on employees. On the basis of this, factors such as increasing time and space flexibility of employees, being constantly mobile and online, increasing work tempo, and multiple and complex task responsibilities have shown the necessity of improving the skills of employees to resist work stress. With the increase in digitalization, it is seen that both the number of employees and the number of branches decrease. Factors such as job security, organizational change, uncertainty of the future are the main culprits for job stress. These in turn lead to low performance, absenteeism, dissatisfaction, decreased motivation, work efficiency, and loss of qualified workforce, which will be costly. Banks need to emphasize on giving more importance than ever to the work stress that occurs during the digital transformation process. The subject will be discussed in more detail with a field study.