In recent years, awareness of the impact of hazardous solvents on the environment has increased significantly. Many developments have been implemented to reduce this impact and protect the environment. A development is considered sustainable if it meets the needs of current generations without affecting the needs of future generations. Technologies that involve chemical activities at both industrial and laboratory scale are considered the main factors affecting sustainability. Even small-scale activities of chemists (such as laboratory experiments using significant volumes of hazardous chemicals) have the potential to adversely affect the environment if chemical wastes are disposed of in an uncontrolled manner. Various measures have been developed to protect the environment and chemists in direct contact due to chemical activities (environmental, biological, clinical, etc.). Various terms such as “green chemistry”, “environmentally harmless chemistry”, “clean chemistry” (etc.) have been defined to emphasize the need to carry out chemical activities in an environmentally friendly way. These approaches aim to minimize the consumption of reagents and the generation of waste, and to eliminate hazardous chemicals. In this study, 12 basic principles of green chemistry and green solvents within the scope of these principles were examined.