Cancer cells specifically re-regulate their glucose metabolism for growth, proliferation and spread. The end product of glucose metabolism in mammals can be lactate or CO2 obtained as a result of complete oxidation of glucose through respiration in the mitochondria. Even in the presence of oxygen and fully functioning mitochondria in cancerous tissues, the rate of glucose uptake into the cell and lactate production increase. This event, which makes an important contribution to the progression of cancer, is called the Warburg Effect. Glucose metabolism is carried out by two biochemical processes. The first is glucose uptake, and the second is aerobic glycolysis and conversion of pyruvate to lactate. We have stated that there is a significant increase in the uptake of glucose in cancer cells. However, as we mentioned above, deregulation or changes occur in the glycolysis pathway with the process defined as the Warburg effect, which is the distinguishing feature of cancer. Long non-coding RNAs are also known to mediate the changes in the glycolysis pathway. In this section, we will examine the effects of long non-coding RNAs on the changes in the glycolysis pathway by considering the studies.