The gastrointestinal system consists of the esophagus, small intestine and stomach.The human stomach is divided into four anatomical regions. lower esophageal sphinctercardia located under it, fundusen formed by the upper curvature of the stomach consisting of the section and the corpus located in the central region and the lower region of the stomach.It is the antrumpilor sphincter. Continuous damage to the esophageal, gastric and intestinal mucosa Gastrointestinal (GI) damage due to exposure to internal and external oxidants.The system produces reactive oxygen species (ROS). For this reason, GI system ROT It is quite sensitive for . Because the formation of these ROS damages DNA and It can produce both disease and cancer by producing mutations. taken orally drugs and pathogens, inflammatory cells that contribute to oxidative stress It causes inflammation by activating cytokine producers. Astroduodenal such as ulcers, GI malignancies, and inflammatory bowel disease (IBD) Various GI pathological conditions are deeply related to oxidative stress. Has been shown in studies. Oxidative effects in gastrointestinal system diseases stress, reactive oxygen species (ROS), reactive oxygen species (ROS), nonsteroidal Extensive use of anti-inflammatory drugs (NSAIDs) causes gastric ulcer and upper It causes gastrointestinal system damage such as gastric system bleeding. Therefore, oxidative stress, especially cancer, gastrointestinal, diabetes, cardiovascular, neurological diseases, atherosclerosis and inflammatory.It is responsible for the formation and pathogenesis of many diseases such as disorders. Gastric ulcer caused by oxidative stress is also caused by DNA may cause damage. On the other hand, antioxidant activities prevent this damage can prevent. As a result, gastrointestinal system diseases and oxidative stress.There is a serious relationship between them.