Amyloid Beta Peptides: Utilizing Them to Develop in-vitro Alzheimer's Disease Toxicity Models
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Kılıç,
İ.
H.
(ed.)
2023.
Health Sciences Research: Basic Medicine- IV.
Synopsis
Alzheimer's Disease is a progressive neurodegenerative condition characterized by the formation of neurofibrillary tangles due to intracellular accumulation of amyloid beta plaques and hyperphosphorylated microtubule-associated protein. The use of experimental AD models is very important for understanding AD pathology and developing new treatment approaches. However, it has been observed that data obtained from basic research show very low success rates in clinical studies. For this reason, it is anticipated that evaluating the strengths and limitations of these models in the literature and conducting studies with models covering various aspects of the disease will increase the success of potential treatments. In this chapter, the pathological and molecular characteristics of the use of amyloid beta peptides in in-vitro AD models and the advantages and disadvantages of these uses are discussed.
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Copyright (c) 2023 Hamide Kaya; İbrahim Halil Kılıç; Raziye Akcılar, Hülya Köse, Gökçen Özüpek, İkbal Süheyla Altay, Alpaslan Coşar, Mehmet Cihan Yavaş, Esin Erbek, Güneş Bolatlı, Sevda Lafcı Fahrioğlu, İskender Yılmaz, Sezgin İlgi, Fazilet Şen, Mustafa Sağlam, İbrahim Halil Kılıç, Yasemin Zer, Serap Kurt, Fethi Sırrı Çam, Sina Akan Gümüşburun, Yöntem Demirdöğen, Uğur Vural, Enes Furkan Boyraz, Mehdi Eslami, Çiğdem Eda Balkan Bozlak