21st century skills are skills that include communication, creativity, critical thinking and collaboration and are claimed to make individuals better prepared for the future. Blended learning, on the other hand, is characterized as a model that offers different learning experiences to students and provides learning opportunities integrated with technology by going beyond traditional classroom environments. Blended learning, which combines face-to-face teaching and online learning for a specific purpose, supports students to solve real-life problems, actively participate and learn in context by using online resources and interactive Web 2.0 materials. Research show that 21st century skills targeted and supported in blended learning environments positively affect students' academic achievement, interest levels and motivation. It is thought that blended learning environments are important for students to make sense of information and make connections by providing active participation in the learning process. It is also believed that examining the blended learning approach and 21st century skills will contribute to raising awareness on the subject which will lead to integrating these approaches and skills with each other and raising more equipped individuals.