The engineering design is a very comprehensive term and required a number of different disciplines work together. There are many examples of engineering design studies and design of mechanisms is one of them. The design of mechanisms is one of the focused areas by mechanical engineering field and it includes kinematic synthesis, kinematic analysis, kinetics, dynamics, force and optimization of the mechanisms. The mechanisms can be complex; hence, additional help is needed in solution process. At that point, artificial intelligence (AI) of computer science is a really helpful for the mechanical engineers. Artificial intelligence field was found in 1956 and it is applicable to significant parts of the mechanism design. However, mechanical engineers cannot really apply artificial intelligence principles to mechanism design and as a result, design of mechanisms via AI became an interdisciplinary engineering studies between mechanical engineering and computer engineering. In this chapter of the book, mechanism design with artificial intelligence is focused and some sample applications are shown.