Organizational blindness (myopia) and silo syndrome may be the most important diseases experienced by organizations. Organizational blindness causes businesses to become desensitized to the needs of change and remain closed to innovation, while silo syndrome prevents interdepartmental cooperation and makes it difficult for the business to achieve its overall goals. These two diseases cause businesses to fail to recognize opportunities and threats in the external environment and to lose efficiency through lack of coordination in internal processes. If these syndromes are not taken into account in the short term, they can become chronic in the long term, negatively affecting both the internal functioning of the business and customer satisfaction. To avoid organizational blindness, internal and external control mechanisms should be activated, and strategic intelligence and innovative perspective should be encouraged. To overcome the silo syndrome, communication and cooperation culture should be strengthened and coordination between departments should be ensured. These strategic approaches can contribute to a healthier and more competitive structure. Organizational blindness and silo syndrome are organizational pathologies that need to be carefully addressed for the sustainable success of modern businesses. Diagnosing these diseases early and developing preventive strategies are of great importance for businesses to survive in the long term and increase their competitiveness.