This study examines the effects of digital transformation on business processes and Management Information Systems (MIS) from a strategic perspective. The aim is to examine the integration of digitalization processes with MIS, the effects of this integration on businesses and how digital transformation projects are managed. The study provides a wide range of analyses from technological infrastructure requirements to automation of business processes, the importance of data management and business process innovation. How digital transformation shapes the opportunities and challenges faced by businesses is examined, along with the critical role of MIS in this process. In order to fill the gaps in the literature, topics such as big data analytics, business process innovation and information security are highlighted. In addition, project management methodologies and change management processes are also comprehensively evaluated to ensure the success of digital transformation projects. As a result, the importance of digital transformation and MIS in increasing the competitive advantage of businesses is emphasized and strategic recommendations for future digitalization processes are presented.