Because of their peculiar properties, heterocyclic compounds have become important in the design of pharmaceuticals. It's superior quality. Specifically, because nitrogen-based heterocyclic group atoms are beneficial in multiple ways, these compounds are the pharmaceutical industry is finding new treatments for diseases. Numerous studies have been conducted on creating and utilizing novel bioactive compounds. Even though many types of active compounds have been identified, it is still important to know that benzimidazole stents are still popular. Conversely, research on hybridization has a significant role in the literature and contributes to the diversification of pharmaceutical activity. After the investigation, studying the structure-activity relationships (SAR) of recently created molecules is useful for further research. Based on the information listed above, this chapter discusses the recent accomplishments in synthesizing benzimidazoles and their pharmacological properties. Synthesis methods, structural studies, and significant findings in the pharmaceutical field of research and the analysis of new compounds synthesized by humans show how these methods are different from one another. As a result, it's significant in the literature as a source for researchers who want to acquire the latest information on this topic quickly.