Effector T cells, one of the body's defense cells, have an active role in the regulation of immune responses. These T cells have assumed the role of defense between the soluble substances they produce and the ligand interactions on their surface, and the regulators of the immune system. The CD8+  cells surface receptor control intracellular pathogens. CD8+  cells directly mark cells infected with intracellular organisms. In this study, the interactions between Artemisia annua ligand molecule and CD8+ surface protein molecules were investigated. AutoDock 4 –MGLTolls  package program was used for the calculations, taking into account the basic energy data by determining the best binding site of the protein to the ligand interaction.