Cancer occurs as a result of the transformation of normal body cells into abnormal cells, uncontrolled proliferation, and tumorization because of external or internal factors. It can completely invade the tissue it is in. Cancer is the general name of the disease, which can occur in almost every type of tissue in the body and requires different treatment processes and therapeutic agents. It is among the diseases with the highest mortality rate in the world. For this reason, the search for effective methods for the treatment of the disease is one of the important issues that scientists focus on. Today, many treatment methods are used for cancer types. The most common methods are surgery, chemotherapy, radiotherapy, immunotherapy, and the use of smart drugs. Chemotherapy means treating cancer with drugs. There are many chemotherapeutic agents currently used as drugs worldwide. Bendamustine, daunorubicin, cisplatin, oxaliplatin, carboplatin, and floxuridine are some of these drugs. However, there are two main problems in the use of existing drugs that make cancer treatment difficult. The first of these is drug resistance and the second is the severe side effects of drugs. Platinum-based cancer drugs, which have been used for more than forty years, have very severe side effects. In this context, anticancer activities are investigated by synthesizing drug precursors with less or no side effects by researchers. Especially, in recent years, It is works on benzimidazole metal complexes, which contain transition metals and show cytotoxic effects on cancer cells, but do not harm normal body cells. In addition, zinc is one of the most important trace elements necessary for the development and functioning of living cells. On the other hand, benzimidazole is a heterocyclic aromatic compound formed by the fusion of a benzene ring and an imidazole ring, and represents the class of compounds derived from the benzimidazole nucleus. The benzimidazole ring is a very important pharmacophore with various pharmacological effects such as anticancer, antibacterial, antitumoral, and anthelmintic activity. In recent studies, it has been reported that zinc complex compounds with benzimidazole ligands kill cancer cells and cause less damage to normal body cells. Therefore, particularly, benzimidazole zinc complexes and their anticancer activities was focused on this section.