According to epidemiological studies, cardiovascular disease (CVD) is one of the leading causes of morbidity and mortality among noncommunicable chronic diseases globally. Despite improvements in this disease with living standards and medical advances, the high incidence of CVD remains a major health problem.

The fruits of the Crataegus species, a member of the Rosaceae family and the Crataegus genus, contain high levels of numerous valuable secondary metabolites, including flavonoids, vitamin C, glycosides, anthocyanins, saponins, tannins, and antioxidants and phenolic compounds. Molecules isolated from hawthorn are bioactive compounds with strong antioxidant, radical scavenging activity and help to counteract pathologies due to oxidative stress. Crataegus is among the important plants for the cardiovascular system in nature. The benefits of this herb include improving muscle tone, dilating peripheral blood vessels and coronary vessels, and improving blood flow to the heart. Therefore, it is considered to have an important place in the treatment of heart disease. This study aims to provide a comprehensive overview of research on the effect of Crataegus species on cardiovascular diseases. This section contains information on recent research on the identification of detected active ingredients and their mechanism of action. Existing research involving clinical studies using Crataegus berry was also reviewed.